Журнал клинических случаев

A Study of Amniotic Membrane Graft in Treatment of Chronic Venous Leg Ulcers

Abstract

Asmaa Osman and Ahmed Elbadawy

Aim: To evaluate the efficacy of Amniotic Membrane graft in the treatment of chronic venous leg ulcers. Research Design and Methods: Prospective, randomized, non-blinded study. Eligible patients were randomized to one of 2 groups: Group I: (Control group) included 11 chronic leg ulcers, in which ulcers were treated with conventional moist wound dressings and multilayer compressive bandages. Group II: (Amniotic Membrane group) included 14 leg ulcers. Amniotic membrane was placed in contact with ulcer and held in place with secondary dressing and multilayer compressive bandages. all patients were evaluated for healing rate and change in ulcer size. Results: Healing rate showed significant difference between group I and group II (p = 0.001). Group II (AM) patients demonstrated near complete healing of 14 ulcers in 14-60 days with mean of 33.3 ± 14.7, healing rate range was 0.064- 2.22 and mean of 0.896 ± 0.646 cm2/day with 94% reduction in ulcer size. Taken AM grafts were seen in 28.6% (n=4) of group II. Reduction in ulcer size in taken AM graft was 94.7%, while 93% in non-taken AM graft. Conclusions: Our results suggest that using AM in treat leg ulcers not responding to conventional multilayer compression in patients with non- option chronic venous insufficiency.