Медицинская микробиология и диагностика

Action of Bedaquiline against Rapidly Proliferating Non-Tuberculous Mycobacteria

Abstract

Caitlin Boone*

The efficacy of aquiline in the management of multidrug-resistant tuberculosis has been established. We proposed that this might be a treatment option for nontuberculous mycobacterial infections. The purpose of this investigation was to determine the lowest inhibitory concentration and minimal bactericidal concentration of against 18 strains of rapidly developing mycobacteria. The resazurin microtitre assay broth dilution was used to assess the results. It was shown that the showed a substantial inhibitory effect against the majority of the strains tested, but that for some strains the was significantly greater than the. Mycobacterium flavescens possesses a mutation in the gene linked to natural resistance to, according to a recent discovery. These initially encouraging results show that there is a chance that the treatment could benefit from them.