Журнал клинических случаев

Anaphylactic Shock and Cardiac Arrest Secondary to Aprepitant

Abstract

Rosas D and Raez LE

Antiemetic medications are commonly prescribed, especially in the Oncologic population. Every group of antiemetics have their specific mechanism of action and side effect profile. There is little evidence that NK-1 agonists can produce an anaphylactic shock. We report a case of a 57-year-old female diagnosed with advanced stage lung adenocarcinoma who received aprepitant as a premedication for chemotherapy that caused anaphylactic shock and cardiac arrest. The literature we found on anaphylaxis due to aprepitant, were mainly case reports and case series.We encourage more research on this topic to come to the best treatment approach for these patients for a better outcome.