Метаболомика:Открытый доступ

Automated Reconstruction of Metabolic Pathways of Homo Sapiens involved in the Functioning of GAD1 and GAD2 Genes based on Structural Grammars

Abstract

Rajat K. De *,Somnath Tagore

Modeling and analyzing the architecture of metabolic networks using various computational strategies can be successfully used for studying their internal metabolic dynamics as well as predicting missing links in diseased networks. In the present work, we have implemented our algorithm based on structural grammars, for automated metabolic pathway reconstruction and modeling in metabolic pathways responsible for coding genes responsible for the cause of Type 1 Diabetes mellitus (T1D) in Homo sapiens. We have especially implemented our algorithm for studying the metabolic pairs responsible for the functioning of GAD1 and GAD2 genes. We have also used the algorithm for automated reconstruction of glutamate metabolism, β-alanine metabolism, taurine & hypotaurine metabolism and butanoate metabolism pathway datasets. We have also used the algorithm for missing and multiple link prediction as well as nodal point analysis for all the four metabolic pathways with 90.4-100% accuracy.