Медицинская химия

Benzimidazole Derivatives as Antidiabetic Agents

Abstract

Hassan Y Aboul-Enein, Ahemd A E and Rashedy

Benzimidazoleis an important pharmacophore which was included in several biologically active compounds resulted in the development of several classes of drugs. This review discusses the synthesis of benzimidazole derivatives as a target agents for antidiabeticby different mechanism such as peroxisome proliferator – activated receptor α transcriptional activity, glycosidases receptor, dipeptidyl peptidase IV, glucokinase, human glucagon receptor (hGCGR) antagonist , aldose reductase enzyme and stearoyl- CoA desaturase.