Журнал цитологии и гистологии

Bile Acids Induced Cell Necropotosis

Abstract

Li Wanwei, Liu Menggang, Chen Long, Wu Fang, Song Yao, Shi Yuan and Hu Zhangxue

Bile acids were confirmed as important signal molecule in a lot of physiological processes. Recent studies have demonstrated their roles in regulating cell death pathway. New concept of programmed cell death includes autophagy and necroptosis, two independent pathway of programmed cell death beside apoptosis. The molecular pathway of bile acid induced apoptosis and autophagy were reported by recent studies. However, bile acid induced necroptosis was only noticed by some clinical reports, the molecular pathway is waiting to be discovered. This review aims to summarize the pathway of bile acid induced apoptosis and autophagy and analyze the possible pathway of bile acid induced necroptosis.