Журнал интервенционной и общей кардиологии

Cardiovascular Individuals and Cardiovascular Dysfunction

Abstract

Ioannis Skalidis*

Cardiovascular disease remains a leading cause of morbidity and mortality worldwide, with aging being a significant risk factor. As the global population continues to age, understanding the mechanisms underlying age-related cardiovascular dysfunction and identifying novel therapeutic targets is of paramount importance. One promising avenue of research involves the study of a group of proteins known as sirtuins. Sirtuins are emerging as critical regulators of cellular homeostasis and longevity, and their role in age-related cardiovascular dysfunction is gaining increasing attention. This article explores the role of SIRT1 as a novel target for age-related cardiovascular dysfunction, delving into its mechanisms of action, potential therapeutic implications, and avenues for further research.