Журнал клинических случаев

CD20-Positive T-Cell Large Granular Lymphocytic Leukemia: A Case Report and Literature Review

Abstract

Aliana Meneses Ferreira, Hebert Fabricio Culler, Guilherme Fonseca Hencklain, Luís Alberto De Pádua Covas Lage, Renata de Oliveira Costa, Vanderson Geraldo Rocha, Sheila Aparecida Coelho Siqueira and Juliana Pereira

T-cell large granular lymphocytic leukemia (T-cell LGLL) is a rare disorder characterized by the monoclonal expansion of CD3-positive cytotoxic T cells. Cell morphology and immunophenotyping are the main tools for diagnosis. Typical phenotypic findings include the expression of markers CD3+, CD5+dim, CD8+, CD16+, CD57+, and T-cell receptor (TCR) αβ (+). However, a few cases may present with the CD3+/CD4+ phenotype or the double expression of CD4 and CD8. Similarly, in 20% of cases, TCRγ/δ is positive. In this study, we aimed to describe a rare, unusual case of T-cell LGLL that exhibited expression of the B-cell antigen, CD20. Additionally, we performed a literature review to compare the clinical characteristics of our patient to those of other patients with CD20-positive T-cell LGLL and to seek new therapeutic possibilities.