Журнал клинических случаев

Conversion Therapy for Advanced Gastric Cancer with Apa-tinib Combined with SOX Regimen: A Report of Two Cases and Literature Review

Abstract

Jun Zhang, Yan Dai and Zhongliang Ning

In late state gastric cancer, combination chemotherapy with targeted therapy has been employed, which may control the tumor growth and recurrence. We here report two patients diagnosed with advanced gastric cancer which were treated with SOX regimen combined with apatinib for conversion therapy. After three cycles of this combination treatment, the lymph node metastases and tumor decreased in size, which enabled the surgery (R0 resection), with no recurrence for more than 1 year. We believe that apatinib combined with SOX regimen can increase the possibility of successful surgical resection, and thereby prolonging the progression-free survival of patients with advanced gastric cancer