Журнал противомикробных средств

Cytomegalovirus Disease in Patient with HIV Infection

Abstract

EL Fane M, Sodqi M, EL Rherbi A, Chakib A, Oulad Lahsen A, Marih L and Marhoum EL Filali K

Cytomegalovirus (CMV) disease is a serious condition due to reactivation of previously latent infection or newly acquired infection, it occurs frequently in immunocompromised patients by HIV infection. Even it is actually uncommon in the developed nations with the widespread use of highly active antiretroviral therapy (HAART), CMV disease continues to be among the most common opportunistic infections in patient living with HIV (PLWH) in developing countries. Its severity is linked to its tropism for retina and central nervous system (CNS). It generally affects patients with major deficit in cellular immunity. It’s also an important HIV cofactor that promotes the virus progression and influences morbidity and mortality in PLWH by maintaining immunity dysregulation as well as a chronic systemic inflammation. Retinitis is the major reported CMV disease in PLWH, followed by gastro-intestinal and CNS involvements, rarely lung can be also affected. Diagnosis is achieved by clinical examination; the gold standard is polymerase chain reaction (PCR) in blood and tissue samples. Unless an earlier and effective management, prognosis of CMV disease will be unfavorable. The standard treatment is based on the administration of systemic antiviral drugs. Maintenance treatment is strongly indicated in CMV retinitis to prevent relapses; whereas its indication is discussed in the other organ involvements.