Журнал молекулярных биомаркеров и диагностики

D3 as a Possible Marker Based on D1-D4 Dopamine Receptors Expression in Paranoid Schizophrenia Patients

Abstract

Sorour Ahmadian, Ghazal Delavari, Donya Ghanbari and Davood Zaeifi

Paranoid schizophrenia is one of several types of schizophrenia, a chronic mental illness in which a person loses touch with reality. The classic features of paranoid schizophrenia are having delusions and hearing things that aren’t real. Based on Numerous studies about dopamine and schizophrenia, it suggested that changes in the dopamine systems are in related with schizophrenia, but still there is no clear direct evidence for dopamine hypothesis in schizophrenia.

In terminated examination, 20 paranoid schizophrenia patients mRNA from white blood cells extracted, then cDNA were synthesized. After Quantitive Real-time PCR examination with the related primaries for D1-D4 receptors were terminated and the compared consequences in abundance of genes expression with the normal samples reveal that D1-D4 dopamine receptors were expressed in all samples. Abundance of normal individuals were D1 100%, D2 6.6%, D3 40%, D4 86.6% and for patients were D1 100%, D2 26.6%, D3 33.3%, D4 73.3%. The results of this study reveals significant differences between D3 receptor apply to others. Therefore D3 has a possible clinical significance for using as rapid diagnosis of people who suspicious of paranoid schizophrenia.