Исследования и отчеты в области медицинских наук

Development and Characterization of Human Umbilical Cord Perivascular Cells with Alkaline Phosphatase Activity

Abstract

Haixia Chen

Human Umbilical Cord Perivascular Cells (HUCPVCs) represent a promising source of multipotent stem cells with potential applications in regenerative medicine and tissue engineering. This study focuses on the development and characterization of HUCPVCs with a specific emphasis on their Alkaline Phosphatase (ALP) activity, a critical marker of osteogenic differentiation. HUCPVCs were isolated from human umbilical cords and characterized for their phenotype, differentiation potential and ALP activity using various assays and techniques. Our findings demonstrate that HUCPVCs exhibit robust ALP activity, indicative of their capacity for osteogenic differentiation. Furthermore, we elucidate the molecular mechanisms underlying ALP regulation in HUCPVCs, providing insights into their therapeutic applications in bone regeneration and repair. This study enhances our understanding of HUCPVC biology and informs the development of novel stem cell-based therapies for skeletal disorders and bone injuries.