Журнал исследований мозга

Dopamine Dialogues Exploring the Neurochemistry of Parkinson's

Abstract

Lorenzo Gour*

Parkinson's Disease (PD) is a complex neurodegenerative disorder that affects millions worldwide, impairing motor function and often accompanied by a range of non-motor symptoms. While the exact cause of Parkinson's remains elusive, researchers have identified disruptions in dopamine neurotransmission as a central feature of the disease. In this article, we delve into the intricate neurochemistry of Parkinson's, focusing on the role of dopamine and its implications for understanding and treating this challenging condition. Parkinson's Disease (PD) is a progressive neurodegenerative disorder characterized by motor symptoms such as tremors, rigidity, bradykinesia, and postural instability. Dopaminergic dysfunction, particularly the loss of dopamine-producing neurons in the substantia nigra, lies at the core of PD pathology. To manage the motor symptoms and improve patients' quality of life, dopaminergic medications are the mainstay of treatment. In this article, we explore the various dopaminergic medications used in the management of Parkinson's disease, their mechanisms of action, therapeutic effects, and potential side effects.