Журнал химических наук

Eco-Friendly Synthesis of Pyrimidine and Dihydropyrimidinone Derivatives under Solvent Free Condition and their Anti-microbial Activity

Abstract

Shaaban K Mohamed1,, Ahmed M Soliman, Mahmoud AA El-Remaily, Hosam Abdel-Ghany

Reaction of 2-guanidinobenzimidazole and 2-guanidinebenzoxazole with several active methylene compounds revealed the formation of dihydropyrimidine and dihydropyrimidinone (DHPMs) derivatives via cyclo-condensation reaction. The products were obtained in a good yield, short time and a simple experimental procedure. The synthesized compounds were evaluated for their anti-bacterial activity against Gram-positive and Gram-negative bacteria. The compounds exhibited excellent zone of inhibition against tested bacteria. The investigation of antifungal screening data revealed that all the tested compounds showed moderate to good fungal inhibition. All compounds have been characterized based on IR, 1H-NMR, 13C-NMR and Mass spectrum data, in some cases the structure was established by X-Ray crystallography.