Раковая наука и терапия

Влияние методики и доз лучевой терапии на пациентов с раком легких и метастазами в головной мозг

Abstract

?? ??, ???? ????????, ?? ????????, ??? ??????, ???? ??, ?? ????, ???? ????, ??? ??, ???? ????, ???? ?????? ? ?? ???????

????? ??????? ???????????? ???? ???????? ???????? FSRT ? ???????????? ???????????? ? WBRT ??? ??? ??? ?? ????? ???????????? ? ????????????? ?????????? ? ????????? ? ????? ?????? ? ??????????? ? ???????? ?????. ? ???????????? ??????? ??????? 92 ????????. ??? ??????????? ??? ????????? ????? ???? ?????????? ? ??????? Pinnacle, ????? ??? ???????? ????????? ???????????? ???????????? (1,8-2,0 ??/?) ??? FSRT (2,5-4 ??/?) ? WBRT ??? ??? ??? ? ??????????? ?? ??????? ? ?????????? ????????? ????????? ?????. ????? ???????????? ???? ????????? ????????? ?? 2 ?? 33 ???????, ??????? ???????????? ????????? 15 ???????. ??????? ???? (P=0,050), ?????????????? ??? (P=0,012), ??????????? ????????? ????????? (P=0,016), ?????????? BM (P=0,002), ????? ??????? ??????? (P=0,001), ???? ??????? ??????? (P=0,031) ? ????????????? ????????? (P=0,002) ???? ?????????, ????????? ?? ????? ????????????. ? ????????? ???????????? ???? ?????, ??? ????????? + WBRT, ??? WBRT (P=0,001), FSRT ??????????? ?????, ??? ???????????? ???????????? (P=0,001). ????????????? ?????? ???????, ??? ????????? ???????????? ???? ?????, ??? ????????? + WBRT, ??? WBRT ??? ???, ??? ?? ??????? ????????? ??????? (P=0,001). ??? SCLC ??????? + WBRT ???? ?????, ??? WBRT (P=0,003), ? ??? NSCLC FSRT ???? ?????, ??? ???????????? ??????? ??????? (P=0,024. ??? ????????? ? ????? ?????? ??????? ?????? (≤ 1,5) ??????? ??????? ??????? ???? ?????, ??? ??????? + WBRT, ??? WBRT (P=0,033). ??????? CR ?? ???? ?????? ????????? 6,5%, ??????? PR — 78,3%. ????????????? ????????? ????????, ??? FSRT ? ??????? ???????????? ????? ??????????? CR ? PR (P=0,009). ??? ????????? ? ????? ?????? ? ??????????? ? ???? FSRT ???????????? ???????????? ??????? ???????, ??? ????? ???????? ????????????? ????????? ? ???????? ????? ????????????. ??????? ??????? ??????? ???? ?????, ??? ??????? + WBRT, ??? WBRT.