Журнал косметологии и трихологии

Efficacy and Safety of a New Topical Hair Loss-Lotion Containing Oleanolic Acid, Apigenin, Biotinyl Tripeptide-1, Diaminopyrimidine Oxide, Adenosine, Biotin and Ginkgo biloba in Patients with Androgenetic Alopecia and Telogen effluvium: A Six-month Open-Label Prospective Clinical Study

Abstract

Aurora Garre, Jaime Piquero, Carles Trullas and Gemma Martinez

Objective: The causes of hair loss are multifactorial; therefore, there are multiple potential targets for treatment, and a combination of different active ingredients can be helpful in managing the condition. Androgenetic alopecia and telogen effluvium comprise two of the main types of hair loss, and differ in their pathophysiology. The objective of the study was to evaluate, in male and female individuals with androgenetic alopecia and telogen effluvium, the safety and efficacy of a new hair loss lotion containing a combination of cosmetic ingredients: oleanolic acid, apigenin, biotinyl tripeptide-1, 2-4diamino pyrimidine-3-oxide, adenosine, Ginkgo biloba, and biotin.
Methods: 56 patients with androgenetic alopecia (AGA) or telogen effluvium (TE) completed the study. For 6 months, the product was applied once-daily before bed and left on overnight. Efficacy and safety assessments took place at baseline, 3 months and 6 months. Efficacy was assessed in three ways: phototrichogram to count the total number of hairs and number and of hairs in telogen and anagen, visual clinical assessment by a dermatologist using a 7 point scale that evaluated hair volume/thickness, scalp coverage and overall hair appearance, and patient opinion questionnaire on the effects and additional qualities of the product.
Results: In the whole study sample, the total number of hairs and number of anagen hairs increased significantly (p<0.05). In the subgroup with TE, there was a significant increase in total hairs, and in the AGA subgroup there was a significant increase in total hairs and anagen hairs. On visual clinical assessment, 35.7% of participants were evaluated as having thicker, more voluminous hair, 37.5% had improved general hair appearance and 39.3% had improved scalp coverage. On patient questionnaire, participants reported a reduction in hair loss (79%), increased confidence regarding their hair (86%) and that their hair problem was less visible (79%). The product was rated positively by 100% of participants for texture, smell, and hair condition. There were no adverse events.
Conclusion: This lotion enriched with a mixture of oleanolic acid, apigenin, biotinyl tripeptide-1, 2-4 diamino pyrimidine-3-oxide, adenosine, Ginkgo biloba, and biotin is safe and effective as a topical hair-loss treatment, as proven by the statistically significant increase in total hair fibers and anagen hairs, the increased thickness and scalp coverage on dermatological assessment, and patient self-assessment.