Раковая наука и терапия

Evaluation of Metastatic Cholangiocarcinoma in a Spitz Dog

Abstract

Javad Javanbakht, Farhang Sasani, Fariba Khaki, Shahram Jamshidi, Mehdi Aghamohammad Hassan and Havva Marzban

A 12-year-old spitz breed dog, with progressive neurologic symptoms including seizures, ataxia, mental
depression, walking aimlessly and head pressing was referred to Small Animal Hospital of Veterinary Medicine,
the University of Tehran. The dog was received Diazepam prior to examination and diagnosis, whereas it died
at first day eventually. In physical examination, there was a firm mass with irregular nodular surface, about 8
cm in diameter under the skin of mammary glands region. At necropsy, considerable abdominal ascites, several
masses with different sizes throughout liver lobes and on intestinal serosa were observed. According to histological
adjectives of biliary epithelium due to firm texture of the tumour masses and numerous mitotic figures the tumour
was confirmed as cholangiocarcinoma, and immuniohistochemical results for cytokeratin marker demonstrated
such diagnosis.