Журнал микробного патогенеза

Evaluation of the effect of vaginal infections with Mycoplasma genitalium on antimullerian hormone(AMH) levels and its relationship with abortion by molecular methods

Abstract

Mohammad Yousefzadeh

Mycoplasma genitalium is a sexually transmitted bacterium that causes 15 to 25% of male nongonococcal urethritis and is associated with cervicitis and pelvic inflammatory disease in women.The aim of this study was to investigate the effect of vaginal infections with Mycoplasma genitalium on the level of antimullerian hormone (AMH) and its relationship with abortion by molecular methods in Urmia.Methods: In this study, microbiological methods were used to culture samples suspected of mycoplasma and also to increase the sensitivity to diagnose mycoplasma infections and possible association with the amount of antimullerian hormone in women in the age range of delivery. Genus and species of Mycoplasma RFLP-PCR was used. Results: From 500 intrauterine samples of pregnant women samples, extracted DNA, after PCR, 125 sample were positive. The culture results of the samples also showed that 80 cases grew after 2 weeks. 70% of PCR-confirmed samples had a history of miscarriage and 25% of antimullerian hormone levels were abnormal. Genotyping results indicated that the dominant mycoplasma was Mycoplasma genitalium strain G37 of the type.