Молекулярная биология: открытый доступ

Exosomal Micrornas Derived from HIV-infected Macrophages

Abstract

Lisa Garrell

Exosomes are extracellular vesicles that play crucial roles in intercellular communication by transporting various biomolecules, including microRNAs (miRNAs). In the context of HIV infection, exosomes derived from infected cells, particularly macrophages, have gained attention for their potential role in viral pathogenesis and immune modulation. This review focuses on exosomal microRNAs derived from HIV-infected macrophages, exploring their biogenesis, composition, functional roles in viral persistence and immune evasion and potential as biomarkers or therapeutic targets. Understanding the interplay between exosomal miRNAs and HIV pathogenesis can provide insights into novel strategies for disease management and therapeutic intervention.