Thomas Pfister
Chronic pain syndromes characterized by persistent pain that lasts for months or even years, present a significant challenge to healthcare systems worldwide. While genetic factors have long been recognized in the pathophysiology of chronic pain, recent advances in epigenetics have shed new light on how gene expression modifications without changes in the DNA sequence contribute to these conditions. This review explores the emerging role of epigenetics in chronic pain syndromes, focusing on mechanisms such as DNA methylation, histone modification, and noncoding RNAs. By examining the latest research, we aim to provide insights into how epigenetic changes influence chronic pain and highlight potential therapeutic targets for more effective pain management.
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