Сердечно-сосудистые заболевания и диагностика

Gated-SPECT Functional Assessment in Overweight and Obese Patients

Abstract

Adriana C Puente-Barragán, Julieta D Morales-Portano and Lilian G Delgado-Espejel

Introduction: Obesity could be implicated in the modification of myocardial structure and function. Mexico has a 70% prevalence of overweight/obesity; therefore, we suggest assessing these changes with a non-invasive technique as the Gated-SPECT. Methods: This is retrospective observational study. Gated-SPECT assessment was conducted in patients suggesting ischemic heart. Multiple regression analysis was used for predicting the value of age, sex, BMI, DM and hypertension for functional parameters. T-test was used to compare DM groups and one-way ANOVA to compare BMI groups. Results: The model statistically significantly predict BMI and smoking to contribute to the prediction of LVEF, p<0.005, adj. R2 = 0.155. BMI, sex and hypertension added statistically significantly to the EDV prediction, p<0.05. EDV, p < 0.005, adj. R2 = 0.202; and sex, age and hypertension to the ESV prediction, p<0.005, adj. R2 = .251. Significant differences between men and women groups in ESV and EDV were found, p<0.000. Conclusions: BMI is associated with the decrease in LVEF and the elevation of EDV without ventricular dysfunction. Sex, age and hypertension counted for predictors for an increase in ESV. There were no significant differences in the diabetic and non-diabetic groups, however obese diabetic patients have an increase in their EDV values. These alterations could be secondary to preliminary changes in left ventricular remodeling. Gated-SPECT is an effective non-invasive technique to discover alterations in structures before fatal events.