Журнал клинической и медицинской геномики

Genetic Bleeding Risk Score (GBRS) for Patients on Oral Anticoagulant Therapy

Abstract

Risha Nahar, Ishwar C Verma, Roumi Deb, Renu Saxena, Parul Takkar, Sujay Shad, Rajiv Parakh and Prahlad K Sethi

Aims: The present study focussed on deriving and validating a ‘genetic bleeding risk score’ (GBRS) based on genetic and non-genetic factors associated with bleeding in patients on long term anticoagulation therapy.

Patients and Methods: Patients on warfarin (n=53) or acenocoumarol (n=257) long-term therapy were genotyped for twenty one SNPs in six genes. Two GBRSs were developed and validated.

Results: The incidence rate was 16.86 and 4.46 per 100 person-years for minor and major bleeding respectively. The novel GBRS (positive predictive value = 83.3%, specificity = 97.4%) comprised of four parameters; age >65 years, F5 rs6025, VKORC1 rs9934438 and CYP2C9 rs1057911.

Conclusions: The present study is the first to devise and validate a genetic based score for predicting bleeding among first time users of oral anticoagulants.