Журнал клинических случаев

Granulomatosis with Polyangiitis in Patient with Crohn’s Disease

Abstract

Mohamed AK, Mtioui N, Kheyat SS, Zmad MA, Medkouri G, Benghanem Gharbi M, Ramdani B and Bennani Guebessi N

Granulomatosis with polyangiitis and Crohn’s disease are two distinct chronic inflammatory diseases that may involve various organ systems, including the alimentary tract and the oropharynx. In both diseases there is an association with different types of anti-neutrophil cytoplasmic antibodies. We describe a patient previously diagnosed with Crohn’s disease, presenting 20 years later with a rapidly progressive glomerulonephritis and histological evidence of crescentic glomerulonephritis and surrounded by severe interstitial inflammatory infiltrate, ultimately diagnosed as having granulomatosis with polyangiitis.