Журнал клинических случаев

Hoffmann’s Syndrome a Presenting Manifestation of Hypothyroidism

Abstract

Amal Alkhotani

Hypothyrodisim associated with different neuromuscular manifestations. Rarely patient with hypothyroidism may develop muscular pseudohypertrophy a condition called Hoffmann’s syndrome in adults. We report a patient present mainly with myelgia, cramps, calf pseudohypertrophy and persistently elevated Creatine Kinase (CK) with absence of other systemic symptoms of hypothyroidism. His laboratory works revealed severe hypothyroidism. Treatment with L-thyroxine resulted into disappearance of symptoms, normalization of CK and return of calf size to normal. Hypothyrodism should be considered when evaluating patients with neuromuscular complaints even in absence of systemic symptoms.