Журнал иммунобиологии

IL-13 and STAT 6 Gene Variants and Atopic Disorders-A Case Control study from the Northern State of India

Abstract

Syed Mudassar*, Taha Ashraf Qurashi, Gulzar Ahmad Bhat, Mosin Saleem Khan and Roohi Rasool

Inflammatory markers are considered as a common biochemical manifestation among subjects with atopic disorders. The current study was aimed to study the possible association of IL-13 and STAT 6 genes among atopic subjects.

A total of 528 patients diagnosed with atopy and 610 normal subjects were taken for the polymorphic analysis of IL-13 and STAT 6 genes. On stratification, we observed a significant difference between cases and controls with various demographic, life style and dietary factors. Subjects harboring homozygous variant genotypes of IL-13–C1055 T and IL-13–A1512 C showed a statistically significant increase in atopy (OR=1.8 (1.2–2.6), P=0.001) and (OR=6.7 (4.9-9.2), P<0.0001) respectively. Similarly, the variant genotype of STAT 6 G2964 A showed a substantial increase towards atopy when harbor by the subjects (OR=3.7 (2.7–5.1), P<0.0001). Additionally, the above genetic variants of all the genes significantly modified the risk of allergy when stratification was done on the basis of various lifestyle, epidemiological and clinico-pathological characteristics.