Молекулярная и генетическая медицина

Immune Checkpoints of CD8+ T Cells in Acute Myeloid Leukemia

Abstract

Yang J, Liu G, Zhou M, Cheng J, Chen Q and Shen E

Acute myeloid leukemia (AML) is one of the most common types of hematopoietic malignancy in the adults. Induction chemotherapy followed by post-remission is the general treatment for AML patients with high relapse rate and poor prognosis, which is often related to the CD8+ T cell immune status of the AML patients. Herein, we will make a mini review of phenotype-immune checkpoints expression and function of CD8+ T cells in AML based on our data and other groups, and this might indicate the application of immune checkpoints blockade alone or in combination in AML treatment.