Журнал интегративной онкологии

Immunogenetics Exploring the Interplay of Genetics and Immune Function in Health and Disease

Abstract

Arya Amini*

Immunogenetics stands at the intersection of immunology and genetics, unraveling the intricate relationship between our genetic makeup and immune system function. This multidisciplinary field has profound implications for understanding health and disease, as genetic variations influence susceptibility to infections, autoimmune disorders, and responses to treatments. By delving into the genetic basis of immune function, immunogenetics offers insights into personalized medicine, vaccine development, and novel therapeutic approaches. In this article, we embark on a journey through the fascinating realm of immunogenetics, exploring how genetic factors shape our immune system's capabilities and vulnerabilities. One area of active research in immunogenetics is the investigation of genetic determinants of immune cell diversity and function. Immune cells exhibit remarkable heterogeneity in terms of phenotype, function, and activation states, which are influenced by genetic variations and environmental cues. Single-cell RNA sequencing (scRNA-seq) technologies allow researchers to dissect the transcriptional profiles of individual immune cells, unraveling the cellular composition of immune tissues and the molecular pathways driving immune responses.