Экологическая и аналитическая токсикология

Importance of Oxidative Stress Marker in Healthy Females Undergoing Assisted Reproductive Technology

Abstract

Parijatham S, Saikumar P and Chandra Selvi E

Background: Females with primary infertility are subjected to various investigations. Most of them are subjected for stimulation of ovulation. Before subjecting them for stimulation, case selection is important. Knowledge about the basic problems involved in infertility is very important. The male factor should be ruled out. Whatever the reason may be, the females bare the sole responsibility. In infertile couples, oxidative stress (OS) in the females involved where male factor is the cause is estimated. Because the mental stress they face in the society may increase the levels of oxidative stress in them. Aim: Serum level of oxidative stress marker Malondialdehyde (MDA) was done in females in infertile couples where the male factor plays the causative factor. Estimated levels were compared with the MDA levels of fertile females. Materials and methods: 17 infertile couples who were attending fertility clinic at Sree Balaji Medical College and Hospital were selected. In them, the male factor was the reason for infertility. These 17 females were included in the study where the female factors were normal and age, height and weight matched 25 females were included as controls. Results: MDA levels were high (2.8 ± 0.08) in females where other fertility factors were normal compared with fertile females (0.91 ± 0.13). Conclusion: In apparently healthy females where male factor is the etiology, failure to conceive by Assisted Reproductive Technology (ART) may be due to much reason. Increased levels of MDA may be one of the reasons. This may produce difficulty in conception by Assisted Reproductive Technology (ART).