Сердечно-сосудистые заболевания и диагностика

Incident Cardiovascular Disease is more Commonly Associated with Remnant Cholesterol than with LDL Cholesterol

Abstract

Young Park*

Hereditary, observational and clinical mediation studies demonstrate that coursing levels of fatty oils and cholesterol moved in fatty substance rich lipoproteins (remainder cholesterol) can foresee cardiovascular occasions. This study looked at the relationship between major cardiovascular events and a group of older people with high cardiovascular risk's triglycerides and residual cholesterol (remnant-C). This study searched the high risk primary prevention PREDIMED trial population for Major Adverse Cardiovascular Events (MACEs) and determined the baseline lipid profile. The mean age of the participants was: 67 years; index of mass in kg: 30 kg/m²; 43% men; 48% with diabetes) after a middle development of 4.8 years. The association between incident MACEs and lipid concentrations (either as continuous or categorical variables) was evaluated using both unadjusted and adjusted Cox proportional hazard models (N=6,901; n cases=263). Triglycerides' HR (hazard ratio) in multivariable adjusted analyses was as follows: 1.04; 95 percent confidence interval: 1.02 to 1.06 or 0.11 mmol/l, per 10 mg/dl; HDL-C (HR: p 0.001), non-high density lipoprotein cholesterol 1.05; 95% CI: 1.01 to 1.10 or 0.26 mmol/l, per 10 mg/dl; p=0.026) and remainder C (HR: 1.21; 95% CI: 1.10 to 1.33 or 0.26 mmol/l, per 10 mg/dl; MACEs were not associated with HDL-C or low density lipoprotein cholesterol (p=0.001), however. MACEs were also associated with atherogenic dyslipidemia (triglycerides>150 mg/dl (1.69 mmol/l) and HDL-C 40 mg/dl (1.03 mmol/l) in men or 50 mg/dl (1.29 mmol/l) in women) (HR: 1.44; 95% CI: 1.04 to 2.00; p=0.030). Regardless of whether LDL-C levels were on target at 100 mg/dl (2.59 mmol/l), subjects with residual C concentrations below 30 mg/dl (0.78 mmol/l) were more likely to experience MACEs. Triglyceride and remnant-C levels, but not LDL-C, were associated with cardiovascular outcomes in overweight or obese individuals at high cardiovascular risk, independent of other risk factors.