Prince Moye*
Antimicrobial resistance presents one of the most critical challenges to global health, as the ability of microorganisms to withstand treatment with antibiotics, antivirals, antifungals, and antiparasitics threatens the effectiveness of standard therapies. The alarming rise of AMR has spurred significant research into innovative approaches to combat this phenomenon. This comprehensive review explores various groundbreaking strategies being developed to overcome antimicrobial resistance, focusing on novel antibiotics, antimicrobial peptides, bacteriophage therapy, microbiome modulation, nanotechnology, and the utilization of artificial intelligence in drug discovery. Furthermore, phages can be genetically modified to enhance their bactericidal activity or to carry additional genes that degrade bacterial resistance mechanisms. Clinical trials and case studies have demonstrated the potential of phage therapy in treating infections that do not respond to conventional antibiotics, highlighting its promise as a tool against AMR.
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