Журнал клинических случаев

Isolated Subcutaneous Metastasis of Myxoid Liposarcoma: A Case Report

Abstract

Karima Mouden, Amine Souadka, Mouna Khmou, Afaf Semmar, Hanan El Kacemi, Tayeb Kebdani, Sanaa Majjaoui and Noureddine Benjaafar

Background: Subcutaneous metastatic liposarcomas are rare. Differentiation between primary tumors and metastasis of a single liposarcoma represents the main difficulty in diagnosis. In this article, we describe the first report of Subcutaneous metastasis to the neck in the right level IB from liposarcoma originating in the thigh. Case presentation: The present 19-year-old women presented to a complaint of a rapidly growing mass, of the posterior loge of the right thigh with poor definition of adjacent structures, of 9 months’ duration measuring 188 × 97 mm. Microscopic examination of the mass following excision revealed a myxoid liposarcoma. A wide surgical resection was performed, and margins were negative. At this time, the patient showed no metastatic disease and underwent a complementary treatment including irradiation of the right thigh at a dose of 50 Gy delivered in 25 fractions over 38 days. There weren’t any local recurrence or metastases on her 12 months follow up until May 2015 when she presented with a mass in the neck (right level IB). An excisional biopsy was performed by an in June 2015 revealing a myxoid liposarcoma imposing a large re-excision of the tumor bed with 3cm free tumor margin. Microscopic examination of the surgical specimen found clear margins without an involvement of the skin. Differentiation between primary tumors and metastasis of a single liposarcoma was very difficult. The results of the disease extension workup showed no sigh of other metastases no local recurrence until now. Conclusion: To our knowledge, no case of cutaneous metastatic myxoid liposarcoma has been reported until now.