Журнал клинических случаев

Jugular Vein Thrombosis and Recurrent Pleural Effusions in OHSS

Abstract

Chahal R and Pakrashi T

Background: Ovarian hyperstimulation syndrome remains a significant cause of morbidity in ovulation induction. It may be further complicated by thromboembolism and pleural effusions.

Case Report: A 30-year-old nulligravida underwent ovarian stimulation with OCP/Antagonist protocol for in vitro fertilization. Estradiol levels peaked at 2411 pg/mL. Post-stimulation course was complicated by recurrent pleural effusions and an occlusive right internal jugular vein thrombosis. The patient underwent repeated thoracenteses with a drainage of a total of 8350 cc of pleural fluid. The patient received therapeutic anticoagulation and delivered a viable infant at term. Imaging at six weeks postpartum revealed a chronic, non-occlusive deep venous thrombosis involving both the right internal jugular and right subclavian veins.

Conclusion: OHSS results in dynamic changes that contribute to thrombosis and massive fluid shifts. Further research is needed to optimize prevention strategies.