Журнал молекулярных биомаркеров и диагностики

Morphological Characteristics of Neural Tissue during Physiological Aging, Apoptotic, and Cellular Contribution

Abstract

Esther Leuenberger

A growing body of evidence suggests that the brain changes as we age. There is loss of both white and grey matter, degeneration of neurons and synapses, as well as oxidative, inflammatory and biochemical changes. The aforementioned age-related characteristics are linked to autophagy and mitochondria. As a result, we sought to identify the most unusual morphological features of brain nervous tissue as well as characterise the expression of autophagy and mitochondrial immunohistochemical biomarkers in neurons from various human brain zones as they aged.