Молекулярная биология: открытый доступ

Myeloid Cells are an Essential Component of Numerous Inflammatory Processes

Abstract

Alexandria Wells*

In order to coordinate plant life and adaptation, unique membrane receptors that interpret both native and foreign cues have evolved. In order to be able to detect ligands of varying chemical compositions, this large family of receptor proteins have developed ectodomains that are very different from one another. Understanding these signaling systems mechanistically will help answer important questions in cell biology. The latest structurally characterized receptor–ligand interactions and regulatory mechanisms, in addition to novel receptor folds, will be the primary focus of this review. Prostaglandins (PGs) are bioactive lipids that have a place with the eicosanoid class of mixtures. Prostaglandins are known for regulating inflammation, vasodilation, and platelet aggregation, among other physiologic and pathologic functions. Some aspects of the outcome of immune responses, particularly T cell trafficking and diapedesis are influenced indirectly by these characteristics alone. However, PGs also have direct effects on immune system cells that are heavily dependent on the microenvironment during exposure.