Журнал клинических случаев

Myositis and Liver Dysfunction due to Concomitant Therapy of Simvastatin and Itraconazole

Abstract

Qiu-Ting Dong, Yuan-Lin Guo, Na-Qiong Wu, Yi-Da Tang, Li-Xin Jiang and Jian-Jun Li

Simvastatin as an effective cholesterol-lowering medication is widely prescribed to treat cardiovascular diseases. Despite definite safety and efficacy, myopathy and liver dysfunction are the common adverse effects of simvastatin. Little information is available regarding the symptom starting and recovery period for a patient undergoing the side effect. We present here a 65-year-old male patient with both liver dysfunction and myositis due to the concomitant use of itraconazole 400 mg and simvastatin 40 mg daily.