Журнал молекулярных биомаркеров и диагностики

New Markers to Explore Spontaneous Bacterial Peritonitis

Abstract

Fang Fang Wei, Xiaohong Zhang, Zhen Xu and Shaoquan Zhang

Spontaneous Bacterial Peritonitis (SBP) is an ascitic fluid infection without a definitive, surgically treatable, intraabdominal source, accounting for 10 to 30% of cirrhotic patients with ascites. To explore new methods of diagnosing Spontaneous Bacterial Peritonitis (SBP), we prospectively studied 19 Acute-on-Chronic Hepatitis B Liver Failure (ACHBLF) patients with or without Spontaneous Bacterial Peritonitis and 17 Hepatitis B Virus (HBV)-related Liver Decompensated Cirrhosis patients with or without Spontaneous Bacterial Peritonitis. Patients were separated into two groups: SBP group (n=14), non SBP group (n=22). A paracentesis of ascetic fluid was performed. The levels of 40 cytokines in ascetic fluid were measured by using RayBio® Human Cytokine Antibody Array. The results indicated that the levels of RANTES, EOTAXIN EOTAXIN-2, IL-1βand MIP-1αwere higher in the ascitic fluid of the SBP group. An increase in cytokine production in the ascitic fluid of patients with SBP may provide new markers to diagnose SBP more easily and accurately.