Журнал биометрии и биостатистики

Non Clinical Risk Factors of Myocardial Infarction: A Meta-Analysis Approach

Abstract

Sajid MR, Ansar A, Hanif A, Waheed K, Tufail S, Ashraf T and Butt A

Background: Myocardial Infarction (MI) is a coronary heart disease that is one of the main causes of the mortality over the globe. There are various clinical and non-clinical risk factors that can be further classified as modifiable and non-modifiable. This study has explored the role of the some Non Clinical factors like; Gender, Education and Family History with MI using Meta-analysis approach. Methods: The published literature from 1990 to 2015 on MI was collected by using several databases and search engines. A review of the collected literature (28 studies) showed that the studies under analysis were of different origins and had different objectives. For each study, Odds Ratio and 95% confidence intervals was extracted and pooled with a random effect model, weighting for the inverse of the variance. Meta-analysis software version 2.0 was used to analyze heterogeneity analysis and estimate pooled estimates through random effect model. Results: The study has showed that gender (OR=1.391 and 95% C.I.: 1.140, 1.697), family history of heart diseases (OR=3.206 95% C.I.:2.064, 4.981) and low education level or illiteracy (OR=1.552 and 95%C.I.: 1.132, 2.128) are the significant risk factors in developing Myocardial Infarction. Conclusion: This study has concluded that included factors in this study are significantly related to the Myocardial Infarction. Gender difference, family history of heart disease and low education are the important risk factors in causing this fatal disease.