Раковая наука и терапия

P53 Codon 72 Gene Polymorphism and Risk of Oral Squamous Cell Carcinoma in South Indian Population: A Case-Control Study

Abstract

Lakshmi Addala, Kalyan Kumar Ch, Mohan Reddy N, Anjaneyulu V and Sadanani MD

Background: The p53 protein has pleiotropic functions in the modulation of genomic stability of cells. Disruption of p53 activity is commonly found in human cancers. The p53 codon 72 polymorphism is likely to play an important role in the susceptibility to OSCC. We aimed to investigate the association of p53 codon 72 polymorphism with oral squamous cell carcinoma in south Indian population.
 
Methods: We genotyped 150 OSCC patients and 150 controls, using PCR-RFLP method.
 
Results: Our results showed a significant difference in the distributions of p53 codon 72 genotypes among cases and controls. Genotype frequencies of p53 Arg/Arg, Arg/Pro and Pro/Pro were 50.8, 33.9 and 14.4% in the oral squamous cell carcinoma patients and 48.7, 45.1 and 6.2% in the controls, respectively. Arginine/arginine genotype was elevated in controls compared to patients (P<0.0001), where as Proline/Proline (P<0.005) and arginine/proline (P<0.002) genotypes were elevated in patients compared to controls. Arginine allele frequency showed high in cases than Proline.
 
Conclusion: The results of the present study detected that p53 codon 72 polymorphism may contribute to oral squamous cell carcinoma susceptibility in south Indian population.