Раковая наука и терапия

Photodynamic Therapy with Boronated Chlorin as a Photosensitizer

Abstract

Roza G. Nikitina, Michail A. Kaplan, Valentina A. Olshevskaya, Julia S. Rodina, Valentina V. Drozhzhina and Tamila G. Morozova

The purpose of this work was to study the efficiency of photodynamic therapy with boronated chlorin as a photosensitizer for treating experimental tumors such as ?-1 sarcoma and ?-16 melanoma. PDT of ?-1 sarcoma with laser radiation energy density of 300 J/cm2 and power density of 0.42 W/cm2 resulted in complete tumor regression at all three doses of the photosensitizer. Photodynamic therapy of ?-16 melanoma appeared to be the most effective when boronated chlorin at a dose of 10.0 mg/kg and laser radiation energy density of 150 J/cm2 and power density of 0.25 W/cm2 were used. A satisfactory effect of PDT on the tumor was achieved when a dose of 5.0 mg/kg, energy density of 300 J/cm2 and power density of 0.25 W/cm2 were used. At 10 - 21 days after PDT with use of other studied parameters, some animals showed continued tumor growth. Nevertheless, by the end of observation (at day 21), no lung metastases were found in animals. In control, they were detected in up to 43.4 % of cases.