Молекулярная биология: открытый доступ

Production of Recombinant Proteins from the Secretions of Lucilia Sericata Larvae for Wound Healing

Abstract

Masoumeh Bagheri

Maggot therapy is a useful, effective and controlled method using  sterilized larvae Lucilia sericata to treat a variety of acute and chronic wounds. Larval secretions include digestive enzymes, antimicrobial peptides, growth factors, and wound healing agents. However, the use of maggot therapy is an effective method of wound healing.  But, this method has limitations such as disgust and fear of people (placing insect larvae on the wound), long duration of treatment, sterile breeding of larvae, etc. Therefore, using biological science and genetic engineering, it is possible to identify and produce recombinant proteins in larval secretions and then use them in wound healing. Very little research has been done on the production of recombinant proteins in Lucilia sericata larvae. The production of recombinant proteins in Lucilia sericata larvae could revolutionize the pharmaceutical and biotherapy industry and reduce wound healing costs