Медицинская химия

Recent Advances in Natural Product-Based NF-κB Inhibitors as Anticancer and Anti-Inflammatory Agents

Abstract

Arijit Nandi and Anwesha Das

Certain activation of signaling pathways plays a great role in cancer pathogenesis and the growth and progression of the tumor cells. Among the several signaling pathways intensively entangled in cancer progression, NF�??κB is one of the important pathways which are actively explored by researchers [1]. This B cell-specific transcription factor NF�??κB family is first discovered by David Baltimore’s group. It contains five different DNAbinding proteins which are actively involved in the formation of homodimers and heterodimers. NF�??κB proteins are key regulators of innate and adaptive immune responses that can accelerate cell proliferation, inhibit apoptosis, promote cell migration and invasion, and stimulate angiogenesis and metastasis [2]. The normal activation of the NF�??κB is necessary for the survival of the cells and immunity, its deregulation can results development of cancer and multiple inflammatory diseases. Therefore NF�??κB is one of the major targets of anticancer and anti-inflammatory molecule development.