Журнал клинических случаев

Renal Cell Carcinoma Metastasis to Thyroid Gland Associated with Papillary Thyroid Carcinoma: A Case Report and Review of the Literature

Abstract

Francesco Fiorentino, Cira Di Gioia, Giovanni Tortorelli, Mauro Filesi and Francesco Tartaglia

Metastatic thyroid gland tumor is an uncommon finding in clinical practice. We report a case of metastatic renal cell carcinoma (RCC) to the thyroid gland, associated with a Papillary Thyroid Carcinoma (PTC), in a patient who had undergone left nephrectomy for RCC 6 years earlier and operated on in our Institution for a multinodular goiter disease. Immunohistochemistry can be helpful for the differential diagnosis. Metastatic cells of RCC were positive for CD10 and vimentin and negative for thyroglobulin, calcitonin, and TTF-1. Papillary carcinoma cells were positive for Cytokeratin 19, galectin-3, CD56 and Hector Battifora Mesothelial cell monoclonal antibody-1. The association between papillary thyroid carcinoma and RCC is a rare condition and maybe must not be considered a fortuitous development of 2 different neoplasms.