Журнал биомедицинских систем и новых технологий

Spiralization in the Construction and Development of Bio-Systems

Abstract

Petrenko Valeriy Mikhaylovich

Spiralization plays an important role in the construction of bio-systems at different levels of individual organization, starting with proteins and DNA. The development of bio-systems, including embryos, occurs through the unevenness their growth in different directions, which leads to their deformation, including the spiralization at different points of mobility of the bio-systems. The spiralization of the developing organ is accompanied by deformation of its mesentery and mesenteric vessels with the division of primary veins into secondary veins and primary lymphatic vessels. Damaging factors can determine the excessiveness of organ spiralization and its mesentery, such as, ischemia of the walls and death of epithelial cells. This promotes the germination of connective tissue through defects in the epithelium into the cavity of the organ with the formation of its congenital occlusion. Such a critical situation in the normal development of the organ is resolved by anlage of its lymphatic bed, facilitating the removal of blood containing the "fragments" of embryonic structures from the organ and preventing the occurrence of violations in its development.