Медицинская химия

Synthesis and Biological Activities of Novel Pyrazole Derivatives in the Management of Cancer

Abstract

Amit Kumar Gautam*

Cancer is a perplexing and frightening illness. It is the second leading global cause of death. Five new pyrazole compounds were created, and their anti-proliferative effects on people were investigated. The active site of a family of kinase enzymes has been found to be inhibited by the pyrazole analogues. Include CDK (Cyclin-Dependent Kinase). A family of serine threonine protein kinases known as CDKs aid in the beginning, continuation, and end of cell cycle events. Pyrazole derivatives ability to stop the growth of endothelial cells the endothelial cell growth is inhibited by hydroxypyrazolocarboxaldehyde. The proliferation of tumor cells is inhibited by new pyrazoles, although hydroxypyrazoloquinolin-4 exhibits superior action in this regard.