Раковая наука и терапия

TCGDB: A Compendium of Molecular Signatures of Thyroid Cancer and Disorders

Abstract

Ankush Bansal and Jayashree Ramana

Thyroid cancer is the most prevalent endocrine malignancy affecting 213,000 people every year worldwide. There are many types of thyroid disorders including hyperthyroidism, hypothyroidism, Goitre, Hashimoto’s thyroiditis. The ocean of information that is available with respect to molecular markers related to Thyroid disorders and cancer is scattered in literature. Thyroid Cancer and Disorder Gene Database (TCGDB) is a compendium of genes and miRNAs experimentally known to be involved in thyroid cancer and disorders. The current release of TCGDB houses a collection of 250 genes and 120 unique miRNAs compiled by manual screening of numerous research articles. The literature references have been provided for each entry to establish its association with thyroid cancer and disorders. TCGDB provides information on miRNA in body fluids which can be used as potential biomarkers for diagnosis of thyroid cancer and disorders. We have also analysed the overlap of thyroid cancer related miRNAs with other type of cancers. The database provides various browse and search options for users to quickly extract required information. TCGDB will help in prioritizing, systematic testing and comparative analysis of candidate biomarkers for cancer diagnosis. It is freely accessible at http://www.juit.ac.in/attachments/tcgdb/index.php