Журнал клинических случаев

Tigecycline−Induced Triad of Adverse Effects − Acute Pancreatitis, Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) and Thrombocytopenia: A Rare Case Report

Abstract

Khalil Zahalka and Tsvi Gregory Avishai

Reports about Tigecycline-induced acute pancreatitis are raising, Tigecycline-induced thrombocytopenia and hypersensitivity reactions are also fairly reported leading to severe clinical complications. We report a rare case of a triad adverse effects associated with Tigecycline treatment in a 5-year-old boy who received Tigecycline for treatment of disseminated mycobacterium abscessus within three months. Tigecycline was a leading cause for all three adverse effects especially acute pancreatitis based on the Naranjo adverse drug reaction probability scale, adverse effects were addressed by a multidisciplinary team and even discontinuation of Tigecycline was done twice with a desensitization re-challenge protocol. Clinicians should be aware of these possible adverse effects especially acute pancreatitis and mainly in high-risk patients.