Журнал молекулярной гистологии и медицинской физиологии

Tissue Microarrays: Powerful Tools for Molecular Morphology

Abstract

Vikrant Singh

Tissue microarray (TMA) is a new technology that has been created to improve the effectiveness of molecular profiling in cancer research by allowing researchers to quickly conduct large-scale investigations while lowering experimental variables and preserving valuable tissue samples. The approach enables the simultaneous examination of protein or genes in an array of hundreds of paraffin-embedded cored tissue specimens on a single glass slide. Immunohistochemistry, fluorescent-dye tests, and in situ hybridization can all be used to assess TMAs (ISH). TMAs enables the quick analysis of normal and cancer tissues and are particularly valuable for cancer biomarker validation investigations.