Журнал цитологии и гистологии

Toxicological Evaluations of the Crude Extracts and Fractions of Moringa stenopetala Leaves in Liver and Kidney of Rats

Abstract

Bekesho Geleta, Makonnen E and Debella A

Background: Moringa stenopetala is a medicinal plant that has been used in Ethiopian tradi-tional medicine as a remedy for treatment of hypertension, diabetes, malaria and stomach pain. Objective: The aim of this study was to assess the safety of the extracts and fractions of Moringa stenopetala leaves in liver and kidney of female Wistar rats. Methods: For acute toxicity study, the female Wistar rats were randomly divided into control and treatment groups that received distilled water and oral administration of single dose of 5000 mg/kg (n=5) extract, respectively and followed for 14 days. For repeated daily administration of extract, the female Wistar rats were Female Wistar rats were randomly divided into control and treatment groups (n=6). Treatment groups were given daily extracts (250, 500, and 1000 mg/kg) orally. Whereas, normal control received distilled water ad libitum for 15 days. On the 16th day the blood was sampled to evaluate the effect on liver and kidney using clinical chemistry analyzer. Results: The acute toxicity study found no signs of toxicity; hence LD50 was greater than 5000 mg/kg. The biochemical test revealed that extracts produced a rise in liver in a dose de-pendent manner but no effect on kidney function indicators compared with normal control. Conclusion: These findings revealed that the extracts of Moringa stenopetala are toxic to liver but not to kidney.