Ahmed Salah Ali* and Ahmed Soliman
Tumour Regressive Grade (TRG), margins and histopathology grade are the way to reach a strategy for addition of adjuvant chemotherapy or not, however lack of solid date about the exact benefit of the sole adjuvant therapy makes it very challenging, so the patients' decisions are very considerable in such cases, especially with high risk features; high TRG, positive margins and poor performance status, as the benefits of pre surgical chemotherapy may not be so clear. High TRG score and borderline performance status may be factors behind a decision to stop treatment after the surgery.
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