Журнал исследований мозга

Understanding the Peritumoural Brain Zone of Glioblastoma: CDK4 and EXT2 Could Be Potential Malignancy-Drivers

Abstract

Louis Rokka

Glioblastoma (GBM) is the most aggressive and lethal primary brain tumor in adults. Despite significant advances in medical science, the prognosis for GBM patients remains poor, with a median survival of around 15 months. One of the primary challenges in treating GBM is the invasive nature of the tumor, leading to tumor cells infiltrating surrounding healthy brain tissue beyond the visible tumor mass. This region surrounding the tumor, known as the peritumoural brain zone, plays a crucial role in the progression and recurrence of GBM. Recent research has shown that several genetic factors, including CDK4 and EXT2, could play vital roles in driving malignancy within this zone. This article aims to shed light on the importance of understanding the peritumoural brain zone of GBM and explore the potential implications of CDK4 and EXT2 in the tumor's malignancy.